PRODUCTION AND BIOMEDICAL POTENTIAL OF SILICA NANOPARTICLES
- Authors
-
-
A. D. Akinwekomi
Department of Metallurgical and Materials Engineering, Federal University of Technology, PMB 704, Akure, Ondo State, Nigeria
-
S. O. Seidu
Department of Metallurgical and Materials Engineering, Federal University of Technology, PMB 704, Akure, Ondo State, Nigeria
-
- Keywords:
- Silica nanoparticles, biomedical application, structural diversity, toxicity
- Abstract
-
Silica nanoparticles (SiNPs) are extensively utilized in the biomedical space as a result of their greater biocompatibility, thermal steadiness, as well as the capability to easily functionalize their surfaces. Nevertheless, the studies of the toxicity of SiNPs are still at their initial levels and the mechanisms of the toxicity of SiNPs are not completely known yet. This paper is a review of the latest developments in manufacturing silica nanoparticles, focusing especially on green and sustainable techniques, such as thermal and wet methods. It is also an analysis of the structural diversity of SiNPs, including solid, mesoporous, shaped, and etched nanoparticles, and the discussion of their toxicological assessment to help justify the safe and effective use of SiNPs in biomedicine
- References
-
Albert, G-C., Sina, S., Tom, A. J. W., Relinde, J. A. V-D-M., Ramakrishna, K., Maarten, B., Alfons, V-B., and Marijn A.V-H. (2021), In situ study of the wet chemical etching of sio2 and nanoparticle sio2 core?shell nanospheres, ACS Appl. Nano Mater., 4,1136?1148.
Amiri, M., Salavati-Niasari, M., and Akbari, A. (2017), A magnetic CoFe2O4/SiO2 nanocomposite fabricated by the sol-gel method for electrocatalytic oxidation and determination of L-cysteine. Microchim Acta, 184(3), 825–833.
Araichimani, P., Prabu, K., Kumar, G.S., Karunakaran, G., Van Minh, N., Karthi, S., Girija, E., Kolesnikov, E. (2020), Rare-earth ions integrated silica nanoparticles derived from rice husk via microwave-assisted combustion method for bioimaging applications, Ceram Int 46(11),18366–18372.
Arriagada, F. J., and Osseo-Asare, K. (1999), Synthesis of nanosize silica in a nonionic water-in-oil microemulsion: effects of the water/ surfactant molar ratio and ammonia concentration. J. Colloid Interface Sci., 211,210?220.
Baeza, A., and Vallet-Regi, M. (2020), Mesoporous silica nanoparticles as theranostic antitumoral nanomedicines, Pharmaceutics, 12 (10).
Bagwe, R. P., Yang, C., Hilliard, L. R., and Tan, W. (2004), Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir, 20, 8336?8342.
Barrabino, A. (2011). Synthesis of mesoporous silica particles with control of both pore diameter and particle size. Master’s thesis
Biju, V. (2014), Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy, Chem Soc Rev, 43(3),744–764.
Bolong, X., Shanshan, L., Rui, S., and Huiyu L. (2023), Multifunctional mesoporous silica nanoparticles for biomedical applications, signal transduction and targeted therapy, 8,435
Bondarenko, O., Mortimer, M., Kahru, A., Feliu, N., Javed, I., Kakinen, A., and Zhao, Y. (2021), Nanotoxicology and nanomedicine: the yin and yang of nano-bio interactions for the new decade, Nano Today, 39,101184.
Brinker, C.J., and Scherer, G.W. (2013). Sol-gel science: the physics and chemistry of sol-gel processing, academic press, New York
Cai, Q., Luo, Z.S., Pang, W.Q., Fan, Y.W., Chen, X.H., and Cui, F.Z. (2001), Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium. Chem Mater, 13(2),258–263.
Caras, A. (2011). Glucan particle delivery of mesoporous silicadrug nanoparticles, UMASS Medical School.
Chandra, P. and Segal, E. (2016). Nanobiosensors for personalized and onsite biomedical diagnosis, 2nd ed., The Institution of Engineering Technology, 637.
Chandra, S., Das, P., Bag, S., Laha, D., and Pramanik, P. (2011). Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparticles. Nanoscale, 3,1533?1540.
Chang, J. S., Chang, K. L. B., Hwang, D. F., and Kong, Z. L. (2007), In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ. Sci. Technol., 41, 2064?2068.
Chauhan, V. P., Popovic?, Z., Chen, O., Cui, J., Fukumura, D., Bawendi, M. G., and Jain, R. K. (2011), Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angew. Chem., Int. Ed., 50, 11417?11420.
Chen, D., Li, L., Tang, F., and Qi, S. (2009), Facile and scalable synthesis of tailored silica “nanorattle” structures. Adv. Mater., 21,3804?3807.
Chen, F., Zhang, H., Jiang, L., Wei, W., Liu, C., and Cang, S. (2019). Enhancing the cytotoxic efficacy of combined effect of doxorubicin and cyclosporin encapsulated photoluminescent graphene dotted mesoporous nanoparticles against lung cancer cell-specific drug targeting for the nursing care of cancer patients, J. Photochem. Photobio. B, 198,111578.
Chen, J., Qiu, X., Ouyang, J., Kong, J., Zhong, W., and Xing, M. M. (2011), pH and reduction dual-sensitive copolymeric micelles for intracellular doxorubicin delivery, Biomacromolecules, 12, 3601?3611.
Chen, Y., Chen, H., Zeng, D., Tian, Y., Chen, F., Feng, J., Shi, J. (2010), Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery, ACS Nano, 4, 6001.
Chen, Z., Tan, Y., Xu, K., Zhang, L., Qiu, B., Guo, L., Lin, Z., and Chen, G. (2016), Stimulus-response mesoporous silica nanoparticlebased chemiluminescence biosensor for cocaine determination. Biosens Bioelectron, 75,8–14.
Chowdhury, M.A. (2018), Silica materials for biomedical applications in drug delivery, bone treatmentor regeneration, and MRI contrast agent. Rev J Chem, 8(2),223–241.
Chung, T. H., Wu, S. H., Yao, M., Lu, C. W., Lin, Y. S., Hung, Y., Huang, D. M., et al. (2007), The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3t3-l1 cells and human mesenchymal stem cells. Biomaterials, 28, 2959?2966.
Da Silva Bruckmann, F., Zuchetto, T., Ledur, C.M., Dos Santos, C.L., Da Silva, W.L., Fagan, S.B., Da Silva, I.Z., and Rhoden, C.R.B. (2022), Methylphenidate adsorption onto graphene derivatives: theory and experiment, New J. Chem., 46,4283–4291.
Dasgupta, S., Auth, T., and Gompper, G. (2014), Shape and orientation matter for the cellular uptake of nonspherical particles. Nano Lett., 14, 687?693.
Devi, M.G., and Balachandran, S. (2016), A review on synthesis, characterization, and applications of silica particles international. Journal of advanced. Eng Technol, 4,249–255.
Dhinasekaran, D., Raj, R., Rajendran, A.R., Purushothaman, B., Subramanian, B., Prakasarao, A., Singaravelu, and G. (2020), Chitosan mediated 5-Fluorouracil functionalized silica nanoparticle from rice husk for anticancer activity. Int J Biol Macromol, 156,969–980.
Di Cristo, L., Movia, D., Bianchi, M.G., Allegri, M., Mohamed, B.M., Bell, A.P., Moore, C, Pinelli, S., Rasmussen, K., Riego-Sintes, J., Prina-Mello, A., Bussolati, O., and Bergamaschi, E. (2016), Proinflammatory effects of pyrogenic and precipitated amorphous silica nanoparticles in innate immunity cells. Toxicol. Sci. 150 (1), 40–53.
Diab, R., Canilho, N., Pavel, I.A., Haffner, F.B., Girardon, M., and Pasc, A. (2017), Silica-based systems for oral delivery of drugs, macromolecules and cells. Adv. Colloid Interface Sci. 249,346–362.
Dimaras, H., Corson, T.W., Cobrinik, D., White, A., Zhao, J., Munier, F.L., Abramson, D. H., Shields, C.L., Chantada, G.L., Njuguna, F., and Gallie, B.L. (2015), Retinoblastoma.Nat. Rev. Dis. Prim., 1,15021.
Feliu, N., and Fadeel, B. (2010), Nanotoxicology: no small matter. Nanoscale, 2, 2514?2520.
Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., and Discher, D. E. (2007), Shape effects of filaments versus spherical particles in flow and drug delivery. Nat. Nanotechnol., 2, 249?255.
Grün, M., Lauer, I., and Unger, K.K. (1997), The synthesis of micrometer and submicrometer-size spheres of ordered mesoporous oxide MCM-41. Adv Mater, 9(3), 254–257.
Han, L., Zhou, Y., He, T., Song, G., Wu, F., Jiang, F., and Hu, J. (2013). One-pot morphology-controlled synthesis of various shaped mesoporous silica nanoparticles. J. Mater. Sci., 48,5718?5726.
He, Q., Zhang, Z., Gao, F., Li, Y., and Shi, J. (2011), In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and pegylation. Small, 7, 271?280.
Hu, C., Sun, J., Zhang, Y., Chen, J., Lei, Y., Sun, X., and Deng, Y. (2018), Local delivery and sustained-release of nitric oxide donor loaded in mesoporous silica particles for efficient treatment of primary open-angle glaucoma. Adv. Health Mater., 7 (23),e1801047
Hu, L., Mao, Z., Zhang, Y., Gao, C. (2011), Influences of Size of Silica Particles on the Cellular Endocytosis, Exocytosis and Cell Activity of HepG2 Cells. J. Nanosci. Lett., 1, 1?16.
Huang, Q., Lin, X., Lin, C., Zhang, Y., Hu, S., and Wei, C. (2015), A high performance electrochemical biosensor based on Cu 2 O–carbon dots for selective and sensitive determination of dopamine in human serum. RSC Adv, 5(67), 54102–54108.
Huang, X., Li, L., Liu, T., Hao, N., Liu, H., Chen, D., and Tang, F. (2011), The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo, ACS Nano, 5,5390?5399.
Huang, X., Teng, X., Chen, D., Tang, F., and He, J. (2010), The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. Biomaterials, 31, 438?448.
Huang, Y., and Li, S.F.Y. (2013), Electrocatalytic performance of silica nanoparticles on graphene oxide sheets for hydrogen peroxide sensing. J Electroanal Chem, 690,8–12.
Hui, N., Wang, S., Xie, H., Xu, S., Niu, S., and Luo, X. (2015), Nickel nanoparticles modified conducting polymer composite of reduced graphene oxide doped poly (3, 4-ethylenedioxythiophene) for enhanced nonenzymatic glucose sensing, Sensors Actuators, B Chem, 221,606–613.
Ju, J., and Chen, W. (2015), In situ growth of surfactant-free gold nanoparticles on nitrogen-doped graphene quantum dots for electrochemical detection of hydrogen peroxide in biological environments. Anal Chem, 87(3),1903–1910.
Ke, M., Wahab, J.A., Hyunsik, B., Song, K.H., Lee, J.S., Gopiraman, M., and Kim, I.S. (2016), Allantoin-loaded porous silica nanoparticles/polycaprolactone nanofiber composites: fabrication, characterization, and drug release properties, RSC Advances, 6(6),4593–4600.
Knopp, D., Tang, D., and Niessner, R. (2009), Review: bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles. Analytica Chimica Acta, 647(1), 14–30.
Kuswandi, B.J.E.C.L. (2019), Nanobiosensor approaches for pollutant monitoring. Environ Chem Lett, 17(2),975–990
Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., and Zink, J. I. (2012), Mesoporous silica nanoparticles in biomedical applications. Chem. Soc. Rev., 41, 2590?2605.
Liao, Y.T., Lee, C.H., Chen, S.T., Lai, J.Y., and Wu, K.C. (2017), Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma. J. Mater. Chem. B, 5(34),7008–7013
Liberman, A., Mendez, N., Trogler, W.C., and Kummel, A.C. (2014), Synthesis and surface functionalization of silica nanoparticles for nanomedicine. Surf Sci Rep., 69(2),132–158.
Lin, M., Pei, H., Yang, F., Fan, C., and Zuo, X. (2013), Applications of gold nanoparticles in the detection and identification of infectious diseases and biothreats. Adv. Mater., 25, 3490?3496.
Lin, Y. S., and Haynes, C. L. (2010), Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity. J. Am. Chem. Soc., 132,4834?4842.
Lin, Y. S., Abadeer, N., and Haynes, C. L. (2011). Stability of small mesoporous silica nanoparticles in biological media. Chem. Commun, 47, 532?534.
Liu, J., Liu, T., Pan, J., Liu, S., and Lu, G.Q.M. (2018), Advances in multicompartment mesoporous silica micro/nanoparticles for theranostic applications. Annu Rev. Chem. Biomol. Eng., 9,389–411.
Liu, X., Chen, X., Yang, L., Chen, H., Tian, Y., and Wang, Z. (2016), A review on recent advances in the comprehensive application of rice husk ash. Res Chem Intermed, 42(2),893–913.
Lu, F., Wu, S. H., Hung, Y., and Mou, C. Y. (2009), Size effect on cell uptake in well-suspended. uniform mesoporous silica nanoparticles. Small, 5, 1408?1413.
Lu, J., Liong, M., Zink, J.I., and Tamanoi, F. (2007), Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small, 3 (8),1341–1346.
Madajewski, B., Chen, F., Yoo, B., Turker, M.Z., Ma, K., Zhang, L., Chen, P.M., Juthani, R., Aragon-Sanabria, V., Gonen, M., Rudin, C.M., Wiesner, U., Bradbury, M. S., and Brennan, C. (2020), Molecular engineering of ultrasmall silica nanoparticle-drug conjugates as lung cancer therapeutics. Clin. Cancer Res, 26(20),5424–5437.
Mahato, K., Baranwal, A., Srivastava, A., Maurya, P. K., and Chandra, P. (2016), Smart materials for biosensing applications. In Techno-Societal, International Conference on Advanced Technologies for Societal Applications, 421?431.
Mahato, K., Nagpal, S., Shah, M. A., Srivastava, A., Maurya, P. K., Roy, S., Jaiswal, A., Singh, R., and Chandra, P. (2019), Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics. Biotech, 9:57.
Maity, A., and Polshettiwar, V. (2017), Dendritic fibrous nanosilica for catalysis, energy harvesting, carbon dioxide mitigation, drug delivery, and sensing. ChemSusChem, 10(20), 3866–3913.
Mandal, R., Baranwal, A., Srivastava, A., and Chandra, P. (2018), Evolving trends in bio/chemical sensors fabrication incorporating bimetallic nanoparticles. Biosens. Bioelectron, 117,546?56.
Mao, N.D., Lee, S.Y., Shin, H.J., Kwac, L.K., Ko, S.C., Kim, H.G., and Jeong, H. (2018), Biomass fly ash as an alternative approach for synthesis of amorphous silica nanoparticles with high surface area. J. Nanosci. Nanotechnol. 18 (5), 3329–3334.
Mebert, A.M., Baglole, C.J., Desimone, M.F., and Maysinger, D. (2017), Nanoengineered silica: properties, applications and toxicity. Food Chem. Toxicol. 109 (Pt 1),753–770.
Melde, B. J., and Johnson, B. J. (2010), Mesoporous materials in sensing: morphology and functionality at the meso-interface. Anal. Bioanal. Chem., 398,1565?1573.
Na, M., Chen, Y., Han, Y., Ma, S., Liu, J., and Chen, X. (2019), Determination of potassium ferrocyanide in table salt and salted food using a water-soluble fluorescent silicon quantum dots. Food Chemistry, 288, 248–255.
Nozawa, K., Gailhanou, H., Raison, L., Panizza, P., Ushiki, H., Sellier, E., Delville, M. H., and Delville, J. P. (2005), Smart control of monodisperse sto?ber silica particles: effect of reactant addition rate on growth process. Langmuir, 21,1516?1523.
Okoturo-Evans, O., Dybowska, A., Valsami-Jones, E., Cupitt, J., Gierula, M., Boobis, A. R., and Edwards, R.J. (2013), Elucidation of toxicity pathways in lung epithelial cells induced by silicon dioxide nanoparticles. PLoS One, 8 (9), e72363.
Pandey, S., Mewada, A., Thakur, M., Pillai, S., Dharmatti, R., Phadke, C., and Sharon, M. (2014), Synthesis of mesoporous silica oxide/C-dot complex (meso-SiO 2/C-dots) using pyrolysed rice husk and its application in bioimaging. RSC Adv., 4(3),1174–1179.
Parul, K., Sudheer, L., and Sheenam, T. (2023), Synthesis of silica spherical to y-shape nanoparticles: a review with surface modifications and its characterization. Analytical Chemistry Letters, 13(2),106-126.
Prabha, S., Durgalakshmi, D., Rajendran, S., and Lichtfouse, E. (2021), Plant derived silica nanoparticles and composites for biosensors, bioimaging, drug delivery and supercapacitors: a review. Environmental Chemistry Letters, 19,1667–1691
Prieto-Montero, R., Katsumiti, A., Cajaraville, M.P., Lopez-Arbeloa, I., Martinez- Martinez, V. (2020), Functionalized fluorescent silica nanoparticles for bioimaging of cancer cells. Sensors, 20 (19).
Priti, S., Sameer, S., and Sunil, K.S. (2019), Nanosilica: recent progress in synthesis, functionalization, biocompatibility, and biomedical applications. ACS Biomater. Sci. Eng., 5,4882?4898.
Qin, X., Yin, Y., Yu, H., Guo, W., and Pei, M. (2016), A novel signal amplification strategy of an electrochemical aptasensor for kanamycin, based on thionine functionalized graphene and hierarchical nanoporous PtCu, Biosens Bioelectron, 77,752-758.
Qu, W., Meng, B., Yu, Y., and Wang, S. (2017), EpCAM antibody-conjugated mesoporous silica nanoparticles to enhance the anticancer efficacy of carboplatin in retinoblastoma, Mater. Sci. Eng. C Mater. Biol. Appl., 76,646–651.
Rao, V.R. N., Han, H.S., Lee, H., Nguyen, V.Q., Jeon, S., Jung, D.W., Lee, J., Yi, G.R., and Park, J. H. (2018), ROS-responsive mesoporous silica nanoparticles for MR imaging-guided photodynamically maneuvered chemotherapy. Nanoscale, 10 (20),9616–9627,
Ren, D., Xu, J., Chen, N., Ye, Z., Li, X., Chen, Q., and Ma, S. (2021), Controlled synthesis of mesoporous silica nanoparticles with tunable architectures via oil-water microemulsion assembly process. Colloids Surf. A: Physicochem. Eng. Asp., 6:11
Rosu, C., Gorman, A. J., Cueto, R., Dooley, K. M., and Russo, P. S. (2016), Sculpting the internal architecture of fluorescent silica particles via a template-free approach, J. Colloid Interface Sci., 467,321?334.
Saei, A.A., Dolatabadi, J.E.N., Najafi-Marandi, P., Abhari, A., and de la Guardia, M. (2013). Electrochemical biosensors for glucose based on metal nanoparticles. Trends Anal Chem 42,216–227.
Shimura, N., and Ogawa, M. (2007), Preparation of surfactant template nanoporous silica spherical particles by the sto?ber method, effect of solvent composition on the particle size. J. Mater. Sci., 42,5299?5306.
Shirshahi, V., and Soltani M. (2014), Solid silica nanoparticles: applications in molecular imaging. Contrast Media Mol. Imaging, 20:35
Slowing, I.; Trewyn, B. G.; Lin, V. S. Y. (2006), Effect of surface functionalization of mcm-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells. J. Am. Chem. Soc., 128, 14792?14793.
Suzuki, K., Ikari, K., and Imai, H. (2004), Synthesis of silica nanoparticles having a well-ordered mesostructureusing a double surfactant system. J Am Chem Soc, 126(2),462–463.
Tan, S.Y., Teh, C., Ang, C.Y., Li, M., Li, P., Korzh, V., and Zhao, Y. (2017), Responsive mesoporous silica nanoparticles for sensing of hydrogen peroxide and simultaneous treatment toward heart failure. Nanoscale, 9(6),2253–2261.
Tang L., and Cheng J. (2013), Nonporous silica nanoparticles for nanomedicine application. Nano Today, 8(3):290–312.
Trewyn, B. G.; Slowing, I. I.; Giri, S.; Chen, H. T.; Lin, V. S. Y. (2007), Synthesis and functionalization of a mesoporous silica nanoparticle based on the sol-gel process and applications in controlled release. Acc. Chem. Res., 40, 846?853.
Tu, J., Boyle, A. L., Friedrich, H., Bomans, P. H., Bussmann, J., Sommerdijk, N. A., Jiskoot, W., and Kros, A. (2016), Mesoporous silica nanoparticles with large pores for the encapsulation and release of proteins. ACS Appl. Mater. Interfaces, 8,32211?32219.
Tzankov, B., Yoncheva, K., and Lambov, N. (2014), Mesoporous silica nanoparticles as drug carriers. Pharmacia, 61(1),27–37
Vallet-Regí, M., Colilla, M., and González, B. (2011), Medical applications of organic–inorganic hybrid materials within the field of silicabased bioceramics. Chem Soc Rev, 40(2),596–607.
Vallhov, H.; Gabrielsson, S.; Strømme, M.; Scheynius, A.; Garcia-Bennett, A. E. (2007), Mesoporous silica particles induce size dependent effects on human dendritic cells. Nano Lett., 7, 3576?3582.
Verma, M.L.J.E.C.L. (2017), Nanobiotechnology advances in enzymatic biosensors for the agri-food industry. Environ Chem Lett, 15(4), 555–560.
Wang, W., Wang, P., Tang, X., Elzatahry, A. A., Wang, S., Al- Dahyan, D., Zhao, M., Yao, C., Hung, C. T., Zhu, X., Zhao, T. et al. (2017), Facile synthesis of uniform virus-like mesoporous silica nanoparticles for enhanced cellular internalization. ACS Cent. Sci., 3,839?846.
Yang, R., Miao, D., Liang, Y., Qu, L., Li, J., and Harrington, P.D.B. (2015), Ultrasensitive electrochemical sensor based on CdTe quantum dotsdecorated poly (diallyldimethylammonium chloride)-functionalized graphene nanocomposite modified glassy carbon electrode for the determination of puerarin in biological samples. Electrochim. Acta, 173,839?846.
Yang, Y.X., Song, Z.M., Cheng, B., Xiang, K., Chen, X.X., Liu, J.H., Cao, A., Wang, Y., Liu, Y., and Wang, H. (2014), Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells. J. Appl. Toxicol. 34, (4)424–435
Yang, Y., Zhang, M., Song, H., and Yu, C. (2020), Silica-based nanoparticles for biomedical applications: from nanocarriers to biomodulators. Accounts of Chemical Research, 53(8), 1545–1556.
Yogeswaran, U., and Chen, S-M. (2008), A review on the electrochemical sensors and biosensors composed of nanowires as sensing material. Sensors, 8(1), 290–313.
Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipic, M., Frutos, M.J., Galtier, P., Gott, D., Gundert- Remy, U., Kuhnle, G.G., Leblanc, J.C., Lillegaard, I.T, Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R.A., Wright, P. Boon, D. Chrysafidis, R. Gurtler, P. Mosesso, D. Parent-Massin, P. Tobback, N. Kovalkovicova, M., Rincon, A.M., Tard, A., and Lambre, C. (2018), Re-evaluation of silicon dioxide (E 551) as a food additive. EFSA J. 16 (1), e05088.
Yu, Q., Wang, P., Hu, S., Hui, J., Zhuang, J., and Wang, X. (2011), Hydrothermal synthesis of hollow silica spheres under acidic conditions. Langmuir, 27,7185?7191.
Yu, T., Malugin, A., and Ghandehari, H. (2012), Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity.
Zhao, T., Wu, H., Yao, S. Q., Xu, Q. H., and Xu, G. Q. (2010), Nanocomposites containing gold nanorods and porphyrin-doped mesoporous silica with dual capability of two-photon imaging and photosensitization. Langmuir, 26, 14937?14942.
Zhou, X., He, X., Shi, K., Yuan, L., Yang, Y., Liu, Q., Ming, Y., Yi, C., and Qian, Z. (2020), Injectable thermosensitive hydrogel containing erlotinib-loaded hollow mesoporous silica nanoparticles as a localized drug delivery system for NSCLC therapy, Adv. Sci. 7(23),2001442.
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