DRUG DELIVERY AND DEGRADATION OF BIOFILM – A REVIEW
- Authors
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Olaniran Oladayo
Federal University of Technology, Akure.
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- Keywords:
- modified open cast mining, layer-by-layer,, random site working, wounds and inflammation
- Abstract
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A biofilm is an assembly of surface-associated microbial cells that are enclosed in an extracellular polymeric substance matrix. The biodegradability of a biofilm makes it useful in drug delivery since they are easily and rapidly broken down by various bacteria and fungi to release the component drugs. Drug delivery by degradable Layer by Layer (LbL) not only found applications in biomedicine but also has potential applications in other fields such as agriculture, waste management, and the food industries. Pulse drug delivery is important in delivering certain drugs. This means that drug release happens over a well-defined period. Controlled drug release is important and useful for example, it takes care of tolerances developed whenever drugs are always available in their target site or to take care of drugs that need dosing at a certain period of the day. New approaches were developed to allow self-control of drug release to maintain a minimum dose of drugs in the bloodstream such that toxicity of drugs in vivo is minimized. Two methods of controlled drug release are common, and they are: temporal and distributional. These were affected by the film assembly's functionality, bendability, cost, and ease of synthesis. Apart from influencing drug release, the efficiency of the drug release can also be improved by polymeric encapsulation by preserving the active form of the drug with its shielding environment. In this work, a degradation study was reviewed on LbL processing technique that encompasses rapid, all-aqueous, conformal fabrication of nanoscale coatings which are highly uniform and tunable, with the capability to spatially present active and control release kinetics for multiple species to produce major trend in the delivery of drugs and other areas of applications.
- Author Biography
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